Publications

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• Brian A Camley, Juliane Zimmermann, Herbert Levine, Wouter-Jan Rappel, Collective Signal Processing in Cluster Chemotaxis: Roles of Adaptation, Amplification, and Co-attraction in Collective Guidance PLoS Comp Biol 12, e1005008 (2016).
• Juliane Zimmermann, Brian A Camley, Wouter-Jan Rappel, Herbert Levine, Contact inhibition of locomotion determines cell-cell and cell-substrate forces in tissues. PNAS 113, 2660 (2016).
• Brian A Camley, Juliane Zimmermann, Herbert Levine, Wouter-Jan Rappel, Emergent Collective Chemotaxis without Single-Cell Gradient Sensing. Phys. Rev. Lett. 116, 098101 (2016).
• Wouter-Jan Rappel, Cell-cell communication during collective migration. PNAS 113, 1471 (2016).
• Monica Skoge, Haicen Yue, Michael Erickstad, Albert Bae, Herbert Levine, Alex Groisman, William F Loomis, Wouter-Jan Rappel Cellular memory in eukaryotic chemotaxis. PNAS 111, 14448-14453 (2014).
• Brian A Camley, Yunsong Zhang, Yanxiang Zhao, Bo Li, Eshel Ben-Jacob, Herbert Levine, Wouter-Jan Rappel, Polarity mechanisms such as contact inhibition of locomotion regulate persistent rotational motion of mammalian cells on micropatterns. PNAS 111, 14770-14775 (2014).
• Marco Tarantola, Albert Bae, Danny Fuller, Eberhard Bodenschatz, Wouter-Jan Rappel, William F Loomis, Cell Substratum Adhesion during Early Development of Dictyostelium discoideum. PLoS One 9, e106574 (2014).
• Amir A Schricker, Gautam G Lalani, David E Krummen, Wouter-Jan Rappel, Sanjiv M Narayan, Human Atrial Fibrillation Initiates via Organized Rather Than Disorganized Mechanisms. Circulation: Arrhythmia and Electrophysiology 7 , 816-824 (2014).
• Fabian Knoch, Marco Tarantola, Eberhard Bodenschatz, Wouter-Jan Rappel, Modeling self-organized spatio-temporal patterns of PIP3 and PTEN during spontaneous cell polarization. Phys. Biol. 11, 046002 (2014).
• David E Krummen, Justin Hayase, David J Morris, Jeffrey Ho, Miriam R Smetak, Paul Clopton, Wouter-Jan Rappel, Sanjiv M Narayan, Rotor stability separates sustained ventricular fibrillation from self-terminating episodes in humans. JACC 11, 046002 (2014).
• Brian A Camley, Wouter-Jan Rappel, Velocity alignment leads to high persistence in confined cells. Phys. Rev. E 89, 062705 (2014).
• Bo Hu, Wouter-Jan Rappel, Herbert Levine, How input noise limits biochemical sensing in ultrasensitive systems. Phys. Rev. E 90, 032702 (2014).
• Juliane Zimmermann, Ryan L Hayes, Markus Basan, José N Onuchic, Wouter-Jan Rappel, Herbert Levine, Intercellular Stress Reconstitution from Traction Force Data Bioph. J. 107, 548-554 (2014).
• Matthew J Gonzales, Kevin P Vincent, Wouter-Jan Rappel, Sanjiv M Narayan, Andrew D McCulloch, Structural contributions to fibrillatory rotors in a patient-derived computational model of the atria. Europace 16 , iv3-iv10 (2014).
• Sanjiv M. Narayan, Kalyanam Shivkumar, David E. Krummen, John M. Miller, and Wouter-Jan Rappel, Panoramic electrophysiological mapping but not electrogram morphology identifies stable sources for human atrial fibrillation: stable atrial fibrillation rotors and focal sources relate poorly to fractionated electrograms. Circ Arrhythm Electrophysiol. 6, 58-67 (2013).
• Brian A. Camley, Yanxiang Zhao, Bo Li, Herbert Levine, Wouter-Jan Rappel, Periodic migration in a physical model of cells on micropatterns. Phys. Rev. Lett. 111, 158102 (2013).
• Herbert Levine and Wouter-Jan Rappel, The physics of eukaryotic chemotaxis Physics Today 66 , 24-30 (2013).
• Matthew J. Gonzales, Gregory Sturgeon, Adarsh Krishnamurthy, Johan Hake, René Jonas, Paul Stark, Wouter-Jan Rappel, Sanjiv M. Narayan, Yongjie Zhang, W. Paul Segars, Andrew D. McCulloch, A three-dimensional finite element model of human atrial anatomy: new methods for cubic Hermite meshes with extraordinary vertices. Med Image Anal. 17 , 525-37 (2013).
• Markus Basan, Jens Elgeti, Edouard Hannezo, Wouter-Jan Rappel, and Herbert Levine, Alignment of cellular motility forces with tissue flow as a mechanism for efficient wound healing. PNAS 110 , 2452-9 (2013).
• Wouter-Jan Rappel and Sanjiv M. Narayan, Theoretical considerations for mapping activation in human cardiac fibrillation. Chaos 23 , 023113 (2013).
• Sanjiv M. Narayan, David E. Krummen, Kalyanam Shivkumar, Paul Clopton, Wouter-Jan Rappel, and John M. Miller, Treatment of atrial fibrillation by the ablation of localized sources: CONFIRM (Conventional Ablation for Atrial Fibrillation With or Without Focal Impulse and Rotor Modulation) trial. JACC 60 , 628-36 (2012).
• Bo Hu, David A. Kessler, Wouter-Jan Rappel, and Herbert Levine, How input fluctuations reshape the dynamics of a biological switching system. Phys Rev E 86 , 061910 (2012).
• Sanjiv M. Narayan, David E. Krummen, Michael W. Enyeart, and Wouter-Jan Rappel, Computational mapping identifies localized mechanisms for ablation of atrial fibrillation. Plos One 7 , e46034 (2012).
• Loomis WF, Fuller D, Gutierrez E, Groisman A, Rappel WJ. William F. Loomis, Danny Fuller, Edgar Gutierrez, Alex Groisman, and Wouter-Jan Rappel, Innate non-specific cell substratum adhesion. Plos One 7 , e42033 (2012).
• Sanjiv M. Narayan, David E. Krummen, and Wouter-Jan Rappel, Clinical mapping approach to diagnose electrical rotors and focal impulse sources for human atrial fibrillation. J Cardiovasc Electrophysiol. 23 , 447-54 (2012).
• Danying Shao, Herbert Levine, and Wouter-Jan Rappel, Coupling actin flow, adhesion, and morphology in a computational cell motility model. PNAS 109 , 6851-6 (2012).
• Wouter-Jan Rappel and Richard A. Firtel, Adaptation in a eukaryotic pathway: Combining experiments with modeling. Cell Cycle 11 , 1051-2 (2012).
• Neda Bostani, David A. Kessler, Nadav M. Shnerb, Wouter-Jan Rappel, Herbert Levine, Noise effects in nonlinear biochemical signaling. Phys. Rev. E 85 , 011901 (2012).
• Kosuke Takeda, Danying Shao, Micha Adler, Pascale G. Charest, William F. Loomis, Herbert Levine, Alex Groisman, Wouter-Jan Rappel, and Richard A. Firtel, Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway. Sci Signal. 5 , ra2 (2012).
• Bo Hu, Wen Chen, Wouter-Jan Rappel and Herbert Levine, Quantifying information transmission in eukaryotic gradient sensing and chemotactic response. J. Stat. Phys. 142 , 1167-1186 (2011).
• Inbal Hecht, Monica L. Skoge, Pascale G. Charest, Eshel Ben-Jacob, Richard A. Firtel, William F. Loomis, Herbert Levine and Wouter-Jan Rappel, Activated Membrane Patches Guide Chemotactic Cell Motility. PLoS Comput Biol. 7 , e1002044 (2011).
• Inbal Hecht, Herbert Levine, Wouter-Jan Rappel and Eshel Ben-Jacob, Self-Assisted amoeboid navigation in complex environments. PLoS ONE 6 , e21955 (2011).
• Bo Hu, Wen Chen, Wouter-Jan Rappel and Herbert Levine, How geometry and internal bias affect the accuracy of eukaryotic gradient sensing. Phys. Rev. E. 83 , 021917 (2011).
• Bo Hu, Herbert Levine and Wouter-Jan Rappel, Design principles and specificity in biological networks with cross activation. Phys. Biol. 83 , 021917 (2011).
• Bo Hu, David A. Kessler, Wouter-Jan Rappel, and Herbert Levine Effects of Input Noise on a Simple Biochemical Switch. Phys. Rev. Lett. 107 , 148101 (2011).
• Bo Hu, William F. Loomis, Herbert Levine and Wouter-Jan Rappel, Phenomenological approach to eukaryotic chemotactic efficiency. Phys. Rev. E 81 , 031906 (2010).
• Charin Modchang, Suhita Nadkarni, Thomas M. Bartol, Wannapong Triampo, Terrence J. Sejnowski, Herbert Levine and Wouter-Jan Rappel, A comparison of deterministic and stochastic simulations of neuronal vesicle release models. Physical Biology 7 , 026008 (2010).
• Mathias Buenemann, Herbert Levine, Wouter-Jan Rappel and Leonard M. Sander, The Role of Cell Contraction and Adhesion in Dictyostelium Motility. Bioph. J. 99 , 50 (2010).
• Bo Hu, Wen Chen, Herbert Levine and Wouter-Jan Rappel, Physical Limits on Cellular Sensing of Spatial Gradients. Phys. Rev. Lett. 104 , 048104 (2010).
• Danny Fuller, Wen Chen, Micha Adler, Alex Groisman, Herbert Levine, Wouter-Jan Rappel and William F. Loomis, External and internal limits to eukaryotic chemotaxis. PNAS 107 , 9656 (2010).
• Danying Shao, Wouter-Jan Rappel and Herbert Levine, Modeling motile cell shapes with the phase field method. Phys. Rev. Lett. 105 , 108104 (2010).
• Monica L. Skoge, Micha Adler, Alex Groisman, Herbert Levine, William F. Loomis and Wouter-Jan Rappel, Gradient sensing in defined chemotactic fields. Integr. Biol. 2 , 659-68 (2010).
• Inbal Hecht, Wouter-Jan Rappel and Herbert Levine, Determining the scale of the Bicoid morphogen gradient. PNAS 106 , 1710 (2009).
• Bo Hu, Wouter-Jan Rappel and Herbert Levine, Mechanisms and constraints on yeast MAPK signaling specificity. Biophys. J. 96 , 4755 (2009).
• Wen Chen, Herbert Levine and Wouter-Jan Rappel, Compartmentalization of Second Messengers in Neurons: a Mathematical Analysis Phys. Rev. E 80 , 041901 (2009).
• Wouter-Jan Rappel and Herbert Levine, Receptor noise and directional sensing in eukaryotic chemotaxis. Phys. Rev. Lett. 100 , 228101 (2008)
• Sanjiv M. Narayan, Dhruv Kazi, David E. Krummen and Wouter-Jan Rappel, Repolarization and activation restitution near human pulmonary veins and atrial fibrillation initiation: a mechanism for the initiation of atrial fibrillation by premature beats. J. Am. Coll. Card. 52 , 1222 (2008)
• Wouter-Jan Rappel and Herbert Levine, Receptor noise limitations on chemotactic sensing. PNAS 105 , 19270 (2008).
• Wen Chen, Herbert Levine and Wouter-Jan Rappel, A mathematical analysis of second messenger compartmentalization. Phys Biol. 10 , 46006 (2008).
• Carsten Beta, Danica Wyatt, Wouter-Jan Rappel, and Eberhard Bodenschatz, Flow Photolysis for Spatiotemporal Stimulation of Single Cells. Anal. Chem. 79 , 3940 (2007)
• Kai Wang, Rex Kerr, Wouter-Jan Rappel and Herbert Levine, Quantifying noise levels of intercellular signals. Phys. Rev. E 75 , 061905 (2007)
• Rex Kerr, Herbert Levine H, Terrence Sejnowski and Wouter-Jan Rappel, Division accuracy in a stochastic model of Min oscillations in Escherichia coli. PNAS 103 , 347 (2006).
• Peter McHale, Wouter-Jan Rappel and Herbert Levine, Embryonic pattern scaling achieved by oppositely directed morphogen gradients. Phys. Biol. 3 , 107 (2006).
• Adi R. Bulsara, John F. Lindner, Visarath In, Andy Kho, Salvatore Baglio, Vincenzo Sacco, Bruno Ando, Patrick Longhini, Antonio Palacios and Wouter-Jan Rappel, Coupling-induced cooperative behaviour in dynamic ferromagnetic cores in the presence of a noise floor. Physics Letters A 353 ,4 (2006).
• Wouter-Jan Rappel, David A. Kessler and Herbert Levine, Directional sensing in eukaryotic chemotaxis: a balanced inactivation model. PNAS 103 , 9761 (2006).
• Loling Song, Sharvari M. Nadkarni, Hendrik U. Bodeker, Carsten Beta, Albert Bae, Carl A. Franck, Wouter-Jan Rappel, William F. Loomis and Eberhard Bodenschatz, Dictyostelium discoideum chemotaxis: Threshold for directed motion. Eur J Cell Biol 85 , 981 (2006)
• Flavio Fenton, Elizabeth Cherry, Alain Karma and Wouter-Jan Rappel, Modeling wave propagation in realistic heart geometries using the phase field method. Chaos 15 , 013502 (2005).
• Hervé Henry and Wouter-Jan Rappel, Dynamics of conduction blocks in a model of paced cardiac tissue. Phys. Rev. E 71 , 051911 (2005).
• Herbert Levine and Wouter-Jan Rappel, Membrane-bound Turing patterns. Phys. Rev. E 72 , 061912 (2005).
• Kai Wang, Yuhai Tu, Wouter-Jan Rappel and Herbert Levine Excitation-Contraction Coupling Gain and Cooperativity of the Cardiac Ryanodine Receptor: A Modeling Approach. Biophys. J. 89 , 3017 (2005).
• Kai Wang, Wouter-Jan Rappel and Herbert Levine, Cooperativity can reduce stochasticity in intracellular calcium dynamics. Physical Biology 1 , 27 (2004).
• Hervé Henry and Wouter-Jan Rappel, The role of M cells and the long QT syndrome in cardiac arrhythmias: Simulation studies of reentrant excitations using a detailed electrophysiological model. Chaos 14 , 172 (2004).
• Juan A. Acebron, Adi R. Bulsara and Wouter-Jan Rappel, Cooperative dynamics in a class of coupled two-dimensional oscillators. Phys. Rev. E 63 , 016210 (2003).
• Juan A. Acebron, Adi R. Bulsara and Wouter-Jan Rappel, Probing a Noisy Oscillator System. Fluct. Noise Lett. 3 , L341 (2003).
• Julien Kockelkoren, Herbert Levine, and Wouter-Jan Rappel, Computational approach for modeling intra- and extracellular dynamics. Phys. Rev. E 68 , 037702 (2003).
• Wouter-Jan Rappel, Peter J. Thomas, Herbert Levine, and William F. Loomis, Establishing direction during chemotaxis in eukaryotic cells. Biophys. J. 83 , 1361-1367 (2002).
• Wouter-Jan Rappel, Herbert Levine, Alistair Nicol and William F. Loomis, Modeling self-propelled deformable cell motion in the Dictyostelium mound; a status report. In The IMA volumes in mathematics and its applications 121 , edited by Philip K. Maini and Hans G. Othmer (Springer, New York c2001).
• Wouter-Jan Rappel, Filament instability and rotational tissue anisotropy; a numerical study using detailed cardiac models. CHAOS 11 , 71 (2001).
• Herbert Levine, Wouter-Jan Rappel and Inon Cohen, Self-organization in systems of self-propelled particles. Phys. Rev. E. 63 , U715 (2001).
• Juan A. Acebron, Adi R. Bulsara, Mario E. Inchiosa and Wouter-Jan Rappel, Noise-mediated dynamics in a two-dimensional oscillator: Exact solutions and numerical results. Europhys. Lett. 56 , 354 (2001).
• Alain Karma and Wouter-Jan Rappel, Phase-field model of dendritic sidebranching with thermal noise. Phys. Rev. E 60 , 3614 (1999).
• Wouter-Jan Rappel, Flavio Fenton and Alain Karma, Spatiotemporal control of wave instabilities in cardiac tissue. Phys. Rev. Lett. 83 , 456 (1999).
• Wouter-Jan Rappel, Alistair Nicol, Armand Sarkissian, Herbert Levine and William F. Loomis, Self-organized vortex state in two-dimensional Dictyostelium dynamics. Phys. Rev. Lett. 83 , 1247 (1999).
• Alistair Nicol, Wouter-Jan Rappel, Herbert Levine and William F. Loomis, Cell-sorting in aggregates of Dictyostelium discoideum. J. Cell Sci. 112 , 3923 (1999).
• Alain Karma and Wouter-Jan Rappel, Quantitative phase-field modeling of dendritic growth in two and three dimensions. Phys. Rev. E 57 , 4323 (1998).
• Alain Karma, Wouter-Jan Rappel, C. Fuh and R. Trivedi, Effects of melt convection on banding during directional solidification of peritectic systems. Metall. Mater. and Trans. A 29 , 1457 (1998).
• W. Losert, H.Z. Cummins, P. Kopczynski, W.-J. Rappel and A. Karma, Doublet cellular pattern in directional solidification selected through spatially periodic perturbations. Phys. Rev. E 68 , 7492 (1998).
• Przemek Kopczynski, Alain Karma and Wouter-Jan Rappel, Cellular multiplets in directional solidification. Phys. Rev. E. 55 , 1282 (1997).
• Marie-Line Chabanol, Vincent Hakim and Wouter-Jan Rappel, Collective chaos and noise in the globally-coupled complex Ginzburg-Landau equation. Physica D 103 , 273 (1997).
• Alain Karma and Wouter-Jan Rappel, Phase-field simulation of three-dimensional dendrites: Is microscopic solvability theory correct? J. of Cryst. Growth., 174 , 154 (1997).
• Alain Karma and Wouter-Jan Rappel, Phase-field method for computationally efficient modeling of solidification with arbitrary interface kinetics. Phys. Rev. E. 53 (1996), R3017.
• Alain Karma and Wouter-Jan Rappel, Phase-field modeling of crystal growth: new asymptotics and computational limits, in Mathematics of Microstructural Evolution, edited by Long-Qing Chen, (The Minerals, Metals, and Materials Society and the Society for Industrial and Applied Mathematics, 1996).
• Wouter-Jan Rappel and Alain Karma, Noise induced coherence in neural networks and excitable elements. Phys. Rev. Lett. 77 , 3256 (1996).
• Przemek Kopczynski, Alain Karma and Wouter-Jan Rappel, Critical role of crystalline anisotropy in the stability of cellular array structures in directional solidification. Phys. Rev. Lett. 77 , 3387 (1996).
• Alain Karma and Wouter-Jan Rappel, Numerical simulation of three-dimensional dendritic growth. Phys. Rev. Lett. 77 , 4050 (1996).
• Alain Karma and Wouter-Jan Rappel, Comment on ``Spatial subharmonics, irrational patterns and disorder in eutectic growth''. Phys. Rev. Lett. 75 (1995), 2444.
• Hermann Riecke and Wouter-Jan Rappel, Coexisting pulses in a model for binary-mixture convection. Phys. Rev. Lett. 75 (1995), 4035.
• Wouter-Jan Rappel, Dynamics of a globally coupled laser model. Phys. Rev. E, 49 (1994), 2750.
• Laurent Fourtune, Wouter-Jan Rappel and M. Rabaud, Phase dynamics near a parity breaking instability. Phys. Rev. E, 49 (1994), R3576.
• Vincent Hakim and Wouter-Jan Rappel, Noise induced periodic behaviour in the globally-coupled complex Ginzburg-Landau equation. Europhys. Lett. 27 (1994), 637.
• Wouter-Jan Rappel and Steven H. Strogatz, Stochastic resonance without an external periodic force. Phys. Rev. E. 50 (1994), 3249.
• Chaouqi Misbah and Wouter-Jan Rappel, Cellular solutions in step flow growth. Phys. Rev. B, 48 (1993), 12193.
• Wouter-Jan Rappel, Asymmetric cell in directional solidification. Phys. Rev. E, 48 (1993), 4118.
• Wouter-Jan Rappel and Hermann Riecke, Parity breaking in directional solidification: numerics versus amplitude equations. Phys. Rev. A 45 (1992), 846.
• Wouter-Jan Rappel and E.A. Brener, The stability of directional solidification cells. J. Physique I (France), 2 (1992), 1779.
• Vincent Hakim and Wouter-Jan Rappel, Dynamics of the globally coupled complex Ginzburg-Landau equation. Phys. Rev. A, 46 (1992), R7347.
• Herbert Levine and Wouter-Jan Rappel, The oscillatory instability in rapid solidification. J. Physique 1 (France)1 (1991), 1291.
• Herbert Levine, Wouter-Jan Rappel and Hermann Riecke, Resonant interaction and traveling solidification cells. Phys. Rev. A 43 (1991), 1122.
• W.-J. Rappel, Patterns in directional solidification, in Nonlinear Structures in Physical Systems, edited by Lui Lam and Hedley C. Morris (Springer-Verlag, New York, 1990).
• E.A. Brener, David A. Kessler, Herbert Levine and Wouter-Jan Rappel, Selection of the Viscous Finger in the 90^o geometry. Europhys. Lett. 13 (1990), 161.
• Herbert Levine and Wouter-Jan Rappel, Numerical study for traveling waves in directional solidification. Phys. Rev. A. 42 (1990), 7475.
• W.-J. Rappel, L.F. Feiner and M.F.H. Schuurmans, Exciton-polariton picture of the free-exciton lifetime in GaAs. Phys. Rev. B 38 (1988), 7874.
• W.-J. Rappel, L.F. Feiner and M.F.H. Schuurmans, Lifetime of free excitons in GaAs, in Excitons in Confined Systems, edited by R. Del Sole, A. D'Andrea and A. Lapiccirella (Springer-Verlag, Berlin, 1987).